205 research outputs found
P16-11. HLA-B57/5801 induces preferential CD27 expression on HIV-Gag but not Nef specific central memory CD8+T cells controlling HIV
International audiencen.
A Unified Approach to the Classical Statistical Analysis of Small Signals
We give a classical confidence belt construction which unifies the treatment
of upper confidence limits for null results and two-sided confidence intervals
for non-null results. The unified treatment solves a problem (apparently not
previously recognized) that the choice of upper limit or two-sided intervals
leads to intervals which are not confidence intervals if the choice is based on
the data. We apply the construction to two related problems which have recently
been a battle-ground between classical and Bayesian statistics: Poisson
processes with background, and Gaussian errors with a bounded physical region.
In contrast with the usual classical construction for upper limits, our
construction avoids unphysical confidence intervals. In contrast with some
popular Bayesian intervals, our intervals eliminate conservatism (frequentist
coverage greater than the stated confidence) in the Gaussian case and reduce it
to a level dictated by discreteness in the Poisson case. We generalize the
method in order to apply it to analysis of experiments searching for neutrino
oscillations. We show that this technique both gives correct coverage and is
powerful, while other classical techniques that have been used by neutrino
oscillation search experiments fail one or both of these criteria.Comment: 40 pages, 15 figures. Changes 15-Dec-99 to agree more closely with
published version. A few small changes, plus the two substantive changes we
made in proof back in 1998: 1) The definition of "sensitivity" in Sec. V(C).
It was inconsistent with our actual definition in Sec. VI. 2) "Note added in
proof" at end of the Conclusio
Efficacy and safety of combination therapy with vildagliptin and metformin versus metformin up-titration in Chinese patients with type 2 diabetes mellitus: study design and rationale of the vision study
Background and aim: Limitations of the currently recommended stepwise treatment pathway for type 2 diabetes mellitus (T2DM), especially the failure of monotherapies to maintain good glycemic control, have prompted use of early, more aggressive combination therapies. The VISION study is designed to explore the efficacy and safety of vildagliptin as an add-on to metformin therapy compared with up-titration of metformin monotherapy in Chinese patients with T2DM. Methods: VISION, a 24-week, phase 4, prospective, randomized, multicenter, open-label, parallel-group study, will include 3312 Chinese T2DM patients aged >= 18 years who are inadequately controlled (6.5% >HbA1c <= 9%) by metformin (750-1000 mg/day). Eligible patients will be randomized to receive either vildagliptin plus metformin or up-titration of metformin monotherapy (5: 1). Patients will also be subgrouped (1: 1: 1: 1) based on their age and body mass index (BMI): <60 years and <24 kg/m(2); <60 years and >= 24 kg/m(2); >= 60 years and <24 kg/m(2); and >= 60 years and >= 24 kg/m(2). Conclusion: The VISION study will test the hypothesis that early use of combination therapy with vildagliptin and metformin will provide good glycemic control and will be better tolerated than up-titration of metformin monotherapy. The study will also correlate these benefits with age and BMI.Cardiac & Cardiovascular SystemsEndocrinology & MetabolismSCI(E)PubMed1ARTICLE1181
Improved measurement of the absolute branching fraction of
By analyzing 2.93 fb of data collected at GeV with the
BESIII detector, we measure the absolute branching fraction , which is consistent with previous measurements within
uncertainties but with significantly improved precision. Combining the Particle
Data Group values of , , and the lifetimes of the and
mesons with the value of measured in this work, we determine the following ratios of
partial widths: and .Comment: 9 pages; 8 figure
Genome-wide association study of endometrial cancer in E2C2
Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC have an increased risk for the disease, suggesting that inherited genetic factors play a role. We conducted a two-stage genome-wide association study of Type I EC. Stage 1 included 5,472 women (2,695 cases and 2,777 controls) of European ancestry from seven studies. We selected independent single-nucleotide polymorphisms (SNPs) that displayed the most significant associations with EC in Stage 1 for replication among 17,948 women (4,382 cases and 13,566 controls) in a multiethnic population (African America, Asian, Latina, Hawaiian and European ancestry), from nine studies. Although no novel variants reached genome-wide significance, we replicated previously identified associations with genetic markers near the HNF1B locus. Our findings suggest that larger studies with specific tumor classification are necessary to identify novel genetic polymorphisms associated with EC susceptibility. Electronic supplementary material The online version of this article (doi:10.1007/s00439-013-1369-1) contains supplementary material, which is available to authorized users
A note on comonotonicity and positivity of the control components of decoupled quadratic FBSDE
In this small note we are concerned with the solution of Forward-Backward
Stochastic Differential Equations (FBSDE) with drivers that grow quadratically
in the control component (quadratic growth FBSDE or qgFBSDE). The main theorem
is a comparison result that allows comparing componentwise the signs of the
control processes of two different qgFBSDE. As a byproduct one obtains
conditions that allow establishing the positivity of the control process.Comment: accepted for publicatio
Search for New Physics with Jets and Missing Transverse Momentum in pp collisions at sqrt(s) = 7 TeV
A search for new physics is presented based on an event signature of at least
three jets accompanied by large missing transverse momentum, using a data
sample corresponding to an integrated luminosity of 36 inverse picobarns
collected in proton--proton collisions at sqrt(s)=7 TeV with the CMS detector
at the LHC. No excess of events is observed above the expected standard model
backgrounds, which are all estimated from the data. Exclusion limits are
presented for the constrained minimal supersymmetric extension of the standard
model. Cross section limits are also presented using simplified models with new
particles decaying to an undetected particle and one or two jets
Measurement of the flavour composition of dijet events in pp collisions at root s=7 TeV with the ATLAS detector
This paper describes a measurement of the flavour composition of dijet events produced in pp collisions at √s=7 TeV using the ATLAS detector. The measurement uses the full 2010 data sample, corresponding to an integrated luminosity of 39Â pbâ1. Six possible combinations of light, charm and bottom jets are identified in the dijet events, where the jet flavour is defined by the presence of bottom, charm or solely light flavour hadrons in the jet. Kinematic variables, based on the properties of displaced decay vertices and optimised for jet flavour identification, are used in a multidimensional template fit to measure the fractions of these dijet flavour states as functions of the leading jet transverse momentum in the range 40Â GeV to 500Â GeV and jet rapidity |y|<2.1. The fit results agree with the predictions of leading- and next-to-leading-order calculations, with the exception of the dijet fraction composed of bottom and light flavour jets, which is underestimated by all models at large transverse jet momenta. The ability to identify jets containing two b-hadrons, originating from e.g. gluon splitting, is demonstrated. The difference between bottom jet production rates in leading and subleading jets is consistent with the next-to-leading-order predictions
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